Determinants of Residual Risk in Secondary Prevention Patients Treated with High- Versus Low-Dose Statin Therapy: The Treating to New Targets (TNT) Study Running title: Mora et al.; Residual risk in TNT
نویسندگان
چکیده
Background-Cardiovascular events occur among statin-treated patients, albeit at lower rates.
منابع مشابه
Determinants of residual risk in secondary prevention patients treated with high- versus low-dose statin therapy: the Treating to New Targets (TNT) study.
BACKGROUND Cardiovascular events occur among statin-treated patients, albeit at lower rates. Risk factors for this "residual risk" have not been studied comprehensively. We aimed to identify determinants of this risk above and beyond lipid-related risk factors. METHODS AND RESULTS A total of 9251 coronary patients with low-density lipoprotein cholesterol <130 mg/dL randomized to double-blind ...
متن کاملReducing residual risk in secondary prevention of cardiovascular disease.
Prevention of cardiovascular disease (CVD) spans the human lifespan, including primordial, primary, and secondary prevention efforts. Extensive evidence from epidemiological, genetic, and animal studies confirms the central importance of elevated low-density lipoprotein (LDL) cholesterol (LDL-C) in atherosclerotic CVD events.1 The Cholesterol Treatment Trialists Collaboration provides perperson...
متن کاملPrediction of cardiovascular events in statin-treated stable coronary patients by lipid and nonlipid biomarkers.
OBJECTIVES The aim of this study was to investigate the relationship between lipid and nonlipid biomarker levels achieved during statin therapy and the incidence of major cardiovascular events (MCVEs) in patients with stable coronary heart disease (CHD). BACKGROUND Several plasma nonlipid biomarkers have been shown to predict MCVEs in population studies. METHODS This is a nested case-contro...
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A plethora of statin survival trials and meta-analyses have demonstrated a substantial reduction in cardiovascular disease (CVD) morbidity and mortality, mainly related to a low-density lipoprotein cholesterol (LDL-C) reduction [1]. One of them, the prospective, randomised, double-blind, secondary prevention Treating to New Targets (TNT, n = 10,001) trial, randomised patients to either 10 or 80...
متن کاملRecent advances in the treatment of atherogenic dyslipidemia in type 2 diabetes mellitus.
Despite best treatment efforts reducing low-density lipoprotein cholesterol, a substantial number of type 2 diabetes mellitus patients still experience progression of cardiovascular risk. Even with intensification of statin therapy, a substantial residual cardiovascular risk remains and atherogenic dyslipidemia is an important driver of this so-called residual risk. Besides statin therapy, new ...
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